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What is free radical scavenging activity?

Updated: 9/18/2023
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Saruma

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Q: What is free radical scavenging activity?
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What is anti-tumor Chemical synthesis?

four new curcurmin analogs (compounds 1, 2, 17 and 18) were synthesized. 17 [3,5-bis(4-hydroxy-3-methoxy-5-methylcinnamyl)N-methylpiperidone] showed high activity with GI50, TGI, and LC50 MG-MID values of 21.3, 70.7, and 97.7 microM, respectively. 18 [3,5-bis(4-hydroxy-3-methoxy-5-methylcinnamyl)-N-ethylpiperidone] showed the highest activity in this study with GI50, TGI, LC50 MG-MID values of 4.4, 33.8, 89.1 microM, respectively. 18 is even more active than curcumin with GI50, TGI, LC50 MG-MID values of 38.4, 35.6, 66.0 microM; respectively. 8 showed moderate selectivity towards Leukemia cell line-subpanel with a ratio of 5.6 (curcumin ratio: 1.2 for the same subpanel). The in vitro anti-tumor screening reveals that the results go hand in hand with the in vitro free radical scavenging effects. The antioxidant effect of these compounds depends mainly on the stabilization of the formed phenoxy free radical for which the p-hydroxy phenyl moiety is essential. o-substitution by electron-donating groups like the o-methoxy group (and to a even higher degree by the ethoxy group) increases the stability of phenoxy free radical, hence increasing both free scavenging and anti-tumor effects. Increasing the alkyl group chain on the N in the series of substituted N-alkyl piperidones as well as the extension of conjugation, increases the stabilization of phenoxy free radical and thereby the activity towards both free radical scavenging and anti-tumor effects. This may be attributed to an increased positive inductive effect and/or increased lipophilicity of the new compounds, a fact which is proven by the superior activities of compounds 17 and 18.


When was Free Radical Research created?

Free Radical Research was created in 1985.


When was Free Radical Centre created?

Free Radical Centre was created in 2005.


What is free-radical halogenation of acetic acid?

free-radical halogenation of acetic acid


What are the 3 steps in the free radical substitution?

The three steps in free radical substitution are initiation, propagation, and termination. In initiation, a free radical is generated. In propagation, the free radical reacts with a molecule to form a new free radical. In termination, two free radicals react with each other to form a stable product, ending the chain reaction.


What is the hybridization of an alkyl free radical?

An alkyl free radical has a SP2 hybridization. This means that the alkyl free radical has one unpaired electron in a sp2 hybrid orbital.


What is a radical biology?

"Radical biology" refers to the role of free radicals in living organisms.


Does BrO3- have a free radical?

No, BrO3- does not have a free radical. It is a stable ion with a formal charge of -1, consisting of a bromine atom bonded to three oxygen atoms.


Is O3 a free radical?

Yes, O3 (ozone) is considered a free radical due to its unstable nature and tendency to react with other molecules by donating or accepting electrons.


Why peroxide effect is not observed with Cl?

Because carbon and iodine elements have same electronegativities and after formation of free radicals, mobility of carbon free radical is much higher than iodine free radical. So carbon free radical can easily attack to form more stable free radical with the substrate. Secondly, due to larger size iodine free radical can easily dimerize to give iodine molecule. Hence, we can not observe peroxide effect


Is BrO3 a free radical?

No, BrO3 is not a free radical. It is a polyatomic ion called bromate. Free radicals are atoms or molecules with unpaired electrons, while BrO3 has a well-defined structure with no unpaired electron.


Is there a free Radical Aces key?

No!