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Rhesus null (Rhnull) phenotype is caused by the deletion of Rh-associated glycoproteins (RHAG) expression on red blood cells (RBCs). Individuals with Rhnull phenotype have RBCs that do not express any of the Rhesus antigens because they cannot be targeted to the RBC membrane. The absence of the Rh complex alters the RBC shape, increases its osmotic fragility, and shortens its lifespan, resulting in a hemolytic anemia that is usually mild in nature. These patients are at risk of adverse transfusion reactions because they may produce antibodies against several of the Rh antigens.

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Q: What is meant by Rhesus Null?
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