11 and 16
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2. It is the early part of the Fibonacci sequence.
22
There does not appear to be a missing number. The sequence is n2 + 1. 12 + 1 = 2 : 22 + 1 = 5 : 52 + 1 = 26 : 262 + 1 = 677. The next number in the sequence is 6772 + 1 = 458330.
The missing number is 18
106