18
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The answer depends on whether you mean the additive opposite (+16) or the multiplicative opposite (-1/16).
16
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What is n? North? Which will mean 10 North by 16 minutes and 50 seconds East. Or is it the longitudinal opposite you require? If you need the opposite of latitude then answer is South 1 degrees 16' 50" East.
16 would be correct for Apex. The options are 8, 2, 32, and 16.