You can only simplify, and by the way you wrote it, it is a bit confusing. I'll assume you mean:
8y + 2 - 18y -5.
In order to do this you must combine like terms, or the same things. We can combine 8y and -18y, as they are both y.
8y - 18y = -10y.
Now we can combine 2 and -5, as they both are plain.
2 - 5 = -3.
Your final answer would be:
-10y - 3.