If you mean locations as in physical location on the earth... Then, differences in pressure between locations can be attributed to their altitudes (or heights) from sea level.
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No, it is the DIFFERENCE between the true and atmospheric pressures.
"in" and "out" are the direction of the pressure.
There is no difference.
Barrons Regents Answer #4
Any pressure difference is irrelevant. The distinction is in the operating fluid. In pneumatic systems, it's a gas. In hydraulic systems, it's a liquid.