They are totally separate things.
Systems of units are standard sets of dimensions in which things are counted and measured.
Significant digits are simply accuracy levels in numbers, such as 3.142 compared to 3.1416.
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their both based on units of measure
Four - zeros between significant digits are significant.
Five. All nonzero digits are significant and zeros in between significant digits are always significant.
Five. All nonzero digits are significant and zeros in between significant digits are always significant.
I assume you mean significant digits. All digits are significant. A zero between other digits is always significant.