243
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225.
It is obvious that 7 is added to get the next number from the previous one.
35
To find the next number in the sequence 4, 11, 25, 53, we can observe the differences between consecutive terms: 11 - 4 = 7, 25 - 11 = 14, and 53 - 25 = 28. The differences (7, 14, 28) double each time, suggesting the next difference should be 56. Adding this to the last number, 53 + 56, we get 109 as the next number in the sequence.
The next number in the sequence would be 25.