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X inactivation is a biological process that occurs in female mammals, where one of the two X chromosomes in each cell is randomly inactivated during early embryonic development. This ensures that females, like males, have one functional copy of the X chromosome, preventing an overdose of X-linked gene expression. The inactivated X chromosome condenses into a structure known as a Barr body and remains largely transcriptionally silent throughout the organism's life. This process is crucial for dosage compensation between the sexes.

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What is the x chromosome inactivation?

this is the process by which one of the two copies of the X-chromosomes present in female animals is inactivated


Occurs when one x-chromosomes is randomly turned off and forms a barr body?

X-chromosome inactivation is a normal process in female mammals where one of the two X chromosomes is randomly inactivated in each cell during embryonic development. The inactivated X chromosome forms a structure called a Barr body, which helps to equalize gene expression between males (XY) and females (XX). This process ensures that both males and females have a similar dosage of X-linked genes.


How is x inactivation an exception to Mendel's laws?

X inactivation is an exception to Mendel's laws because it involves the inactivation of one of the two X chromosomes in females, allowing for dosage compensation between males and females. This process results in the random silencing of one X chromosome and the formation of Barr bodies, altering the expected patterns of inheritance predicted by Mendel's laws.


Why is X-inactivation necessary in individuals with two X chromosomes?

X-inactivation is necessary in individuals with two X chromosomes to ensure that only one X chromosome is active in each cell. This process helps to balance gene expression between the two X chromosomes and prevent an imbalance of gene dosage, which could lead to developmental abnormalities and disorders.


What is x chromosome inactivation in human system?

its not inactive


Does x-inactivation happen in klinefelters syndrome?

X-inactivation typically occurs in individuals with Klinefelter syndrome, which is characterized by having an extra X chromosome (XXY). However, the extra X chromosome in Klinefelter syndrome may not undergo inactivation completely, leading to some cells expressing genes from the additional X chromosome. This can result in a variety of symptoms and characteristics associated with Klinefelter syndrome.


What is the difference between x-inactivation and genomic imprinting?

The difference between them is that : In genomic imprinting : one of the alleles in the two chromosomes ( for example the color of the eyes ) are tend to be heavily methylated, in contrast to the nonimpringting copy of the allele which typically is not methylated. In X-chromosome in activation : As you know in female there are two X chromosomes, so one of the two X xhromosomes is methylated which mean one of the two chromosomes become inactivation.


What accounts for the mosaic color pattern of a female calico cat?

X chromosome inactivation


Is there a way to detect a carrier of autism?

Yes, testing the mother for skewed x-inactivation.


Why does x inactivation occurs in female not in male?

Male carry XY genotype whereas female has XX. Two copies of X chromosome means, there is a great chance of potentially toxic double dose of X-linked genes. It is known that 1000s of genes responsible for growth and cell viability are there in X chromosomes.To avoid the over production of these genes in female (where 2 X chromosomes present), there is a mechanism evolved that transcriptionally control or silence on of these two X chromosome.http://www.nature.com/scitable/topicpage/x-chromosome-x-inactivation-323


How might x inactivation cause patchy hairiness on women who have congenital generalized hypertrichosis even though the disease causing allele is dominant?

Since one X chromosome in each cell is randomly inactivated at some point during development, a woman heterozygous for hypertrichosis would have varying regions of patchy hair if the alleles responsible for the trait were located on the X chromosome. Variation would look similar to the varied tortoise shell coat color pattern on female cats, where the presence of yellow and black (red and gold/blue and cream) is controlled by X chromosome inactivation.


What type of trait might be affected by the inactivation of an x chromosome?

The inactivation of an X chromosome can affect traits that are linked to genes located on the X chromosome. This phenomenon, known as X-inactivation or Lyonization, leads to the expression of only one of the two X chromosomes in females, impacting traits such as color vision, hemophilia, and certain autoimmune disorders. Consequently, females may exhibit a mosaic pattern of traits, with some cells expressing genes from one X chromosome and others from the other. This can result in variable expression of X-linked traits depending on which X chromosome is inactivated in different cells.