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look for a paper being published in "The Oncologist" later this year (2008)
MLXVI (1066) The year that the Normans invaded England.
The year 1008 was a leap year. It was also the oldest known mention of Gundelfingen, a city in Bavaria, Germany. Furthermore it is the birthyear of King Henry I of France.
In the year 422 a number of events occurred, including the end of the Roman-Sassanid War, an earthquake cracked the Colosseum, Pope Boniface 1 died, and more.
The adjective of significance is significant.The adverb of significance is significantly.