Q: What number comes next in the sequence 22-104-268-427?

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A single number, such as 21357, does not define a sequence.

It is not possible to identify a sequence when given only one number, as in this questions.

If you mean: 9, 19, 39, 69 then the next number in the sequence is 109

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A single number, such as 21357, does not define a sequence.

A single number, such as 2481020, cannot define a sequence.

The next number is 0

It is not possible to identify a sequence when given only one number, as in this questions.

A single number cannot define a sequence.

4

You are multiplying each number in the sequence by -2. Therefore, the next number in the sequence after 32 is -64.

Each following number in the sequence is being divided by 4. Therefore, the next number in the sequence is 3/4 = 0.75.

The next number is the sequence 236175969, 48, 12 is 236175861.

The next number in the sequence is 48.

If you mean: 9, 19, 39, 69 then the next number in the sequence is 109

8