Take the paired factors of 108 and make one of the factors negative.
1 x 108 : 2 x 54 : 3 x 36 : 4 x 27 : 6 x 18 : 9 x 12.
So, for example you could have -4 x 27 or 4 x -27.
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Negative. Positives always give positive sign, two of the negatives cancel out, leave one negative sign.
301 is a prime number. Therefore only two numbers multiplied together to give 301 is itself and 1.
91 and 2
44
1 and 82 2 and 41