That depends whether you want to add the numbers, to multiply them, or what.
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To find what two numbers multiply to 858, we need to factorize 858. The prime factorization of 858 is 2 x 3 x 11 x 13. Therefore, the two numbers that multiply to 858 are 39 and 22 (which are the combinations of these prime factors).
There are no two prime numbers in which a product of 100 is possible.
3 and 23 are two prime numbers having a sum of 26.
3 and 53
They are 23 and 5