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When two numbers with different signs are multiplied or divided, the answer is negative.
You add all the numbers with + signs and subtract all that have minus signs.
Then you are adding two rational numbers with different signs! No big deal!
If the two numbers have different signs, then the result will be negative. If the two numbers have the same signs, the result will be positive. This assumes all the numbers are non-zero.
Same rules as adding whole numbers with different signs.