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Leading 0s are not significant digits, nor are trailing 0s after a decimal point in some situations. For example in 01000.01000, the first 0 is not significant as it can be left off without impacting the number. The final three 0s can be significant in some cirmcumstances, such as precise scientific measurements, or non-significant as they do not alter the number's value of 1000.01
No, a leading zero is NEVER a significant digit.
If I understand this convoluted sentence correctly, then think it is true.
All zeros appearing in a number without a decimal point and to the right of the last nonzero digit are not significant unless indicated by a bar. Example: '1300' has two significant figures: 1 and 3. The zeros are not considered significant because they don't have a bar. However, 1300.0 has five significant figures. So 10200 has 3 significant figures because it does not have a decimal point so the zeros after the 2 are not considered significant.
I'll assume you're asking about zeros. Zeros appearing anywhere between two non-zero digits are significant. In the other two cases they could be, but are not necessarily significant.