Issac Newton and Leibniz
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Calculus; by a long shot.
Just about all of calculus is based on differential and integral calculus, including Calculus 1! However, Calculus 1 is more likely to cover differential calculus, with integral calculus soon after. So there really isn't a right answer for this question.
It is certainly used in calculus, just as calculus can be used in trigonometry.
Calculus is the correct spelling.
No. Calculus if a field of mathematics.