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The 1988 Cheyenne 4.3L may die after about 5 minutes for a few possible reasons. These can include:

  • A clogged fuel filter, which prevents fuel from flowing to the engine
  • A weak fuel pump, causing insufficient fuel pressure and volume
  • A faulty ignition system, which may prevent the spark plugs from firing
  • A broken or worn timing belt, which prevents the pistons from firing
  • A clogged air filter, which prevents sufficient air from entering the engine
  • A faulty oxygen sensor, which can cause the engine to run too lean or too rich

It's best to have a qualified mechanic inspect the vehicle to identify the exact cause. This will allow the mechanic to make the necessary repairs to keep the engine running properly.

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