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A 4.3L V6 engine may exhibit symptoms of running on only four cylinders due to issues such as a faulty spark plug, ignition coil, or fuel injector that can cause misfiring or poor combustion. Additionally, vacuum leaks, low compression in one or more cylinders, or problems with the engine's fuel delivery system can also contribute to this issue. Diagnosing the exact cause typically involves checking the ignition and fuel systems, as well as performing a compression test on the cylinders.

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