It refers to the speed of light.
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E = mc2
Einstein's most famous equation, E=MC2 (Energy=Mass x Speed of Light (in a vacuum) Squared) is the equation for Mass-Energy equivalence, which is that the mass of a body is equal to its energy content. It is the core basis for obtaining a nuclear reaction.
E=mc2 E=Energy m=mass c=the speed of light in a vacuum The equation relates mass to energy. Einstein made it.
Mass-energy equivalence
E=mc2 E=energy m=mass c=speed of light Einstein's equation states that Energy equal mass times the speed of light squared