The answer to this varies according to many factors, the main one being speed. speed = distance / time.
E.g, if you were to do 60mph constantly for 100 miles then you would take 90 minutes. However, I doubt that you could constantly keep this speed because of traffic due to either congestion or road works.
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It is 179 miles according to Google Maps.
It will take about 15 hours to drive the 902 miles.
It is 1,122 miles and an estimated 18.5 hours of driving according to Google Maps.
How lond does it take to drive from Johanesburg to Harrismith?
Figure roughly 490 miles on the NYState Thruway ... maybe like 8 hours, depending on stops and how you like to drive.