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It is generally accepted that increasing age is the main time in which periodontium breakdown occurs. Whether this is due to the increased susceptibility of periodontal conditions, the change in plaque composition, or the reaction to plaque composition change is unknown.

Another factor are endopeptidases called collagenase, which breaks down collagen in gingival crevicular fluid.

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Q: List the systemic factors of periodontium breakdown?
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