No such proof can exist within consistent axioms - to add 1 to Graham's number would generate a larger number, and so, by this counterexample, Graham's number cannot be the largest.
It is the largest used in a mathematical proof, because all proofs have been noted in a proof 'by exhaustion', in which all cases (in this case, proofs) have been verified to have smaller constants .
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It is so big that it literally cannot be written down, if each digit of graham's number were written down so small that each digit took up 1 plank volume, the written number would take up a space larger than the observable universe.
Numbers go on to infinity so there is no way to say that there is a largest number. The largest natural number that is actually used is "Graham's number" which is used in field of math known as Ramsey theory.
The long but fool-proof way is to find the complete prime factorisation of the number. Then group all the factors into pairs, rejecting any that cannot be paired. The product of the numbers that are left is the largest square factor.
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64 is the largest number of siblings
The largest factor of any number is the number itself.