The factor pairs (not the GCF) of 16 are (16,1)(8,2)(4,4)
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16 and 21
16, 32 and 48 have a GCF of 16. Whether you added or multiplied to get them doesn't make much difference.
The GCF of 16 and 72 is 8. 16/72 can be reduced to 2/9
The GCF is 1.
The GCF is 2.