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Yes. 4 and 8 have a GCF of 4. 104 and 108 have a GCF of 4. Any set of prime numbers has a GCF of 1, no matter how large or small they are.
You need at least two numbers to find a GCF.
If 3 is not a common factor of a pair of numbers, then other numbers that cannot be common factors are any multiples of 3, such as 6, 9, 12, and so on. This is because if a number is a multiple of 3, it will also be divisible by 3, making it a common factor. Additionally, any prime numbers that are not factors of 3, such as 2, 5, 7, 11, and so on, cannot be common factors either.
Any pair of prime or relatively prime numbers.