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The Lancet published a paper in 2009 titled "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis" where the researchers found that the best antidepressants are Zolfot (sertraline) and Lexapro (escitalopram) in terms of efficacy and acceptability. Sertraline is not as effective as escitalopram but is available as a generic so, depending on your insurance, is less costly.

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Q: What is the strongest antidepressant?
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Related questions

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Nortriptyline is an antidepressant from the tricyclic antidepressant class. (Trade name originally was Pamelor). In low doses it is used as an adjunctive treatment for chronic pain, including headaches and other types. In moderate doses it may be used as an antidepressant or "add-on" medication to another antidepressant.


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