If you go on the wikipedia that might have all the answers and i dont know just giving you a better site.
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If you consider the Jew's harp or the kazoo an instrument, then it would be those. But otherwise, it's the piccolo.
To find the least count of an instrument or measuring device, divide the smallest measurement unit by the total number of divisions on the scale. The least count represents the smallest increment that can be measured or displayed by the instrument.
The smallest stringed instrument is typically the violin, followed by the viola, cello, and double bass as the largest.
I suppose that this value is 1 picovolt (10-12 volt). The symbol is pV.
Factors that determine the precision of an instrument include the resolution of the instrument (smallest readable increment), the stability of the instrument (ability to maintain consistent readings over time), the calibration of the instrument (accuracy of measurements against a known standard), and the repeatability of the measurements (consistency in obtaining the same result with multiple trials).
The instrument that measures the smallest quantities of mass is a mass spectrometer. It can detect mass-to-charge ratios of particles and separate and analyze individual ions based on their mass.