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The Hardy-Weinberg principle is a bit like the "Punnett square for populations". A Punnett square can predict the probability of offspring's genotype based on parents' genotype, or the offsprings' genotype can be used to reveal the parents' genotype. The Hardy-Weinberg principle can be used to calculate the frequency of particular alleles based on frequency diseases. This principle can determine useful but difficult-to-measure facts about a population.

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The Hardy-Weinberg equilibrium is a mathematical model used to predict the frequency of alleles in a population over time, assuming certain conditions are met. It is used by geneticists to study evolution, genetic drift, and natural selection within populations. It helps determine if a population is evolving or if forces such as mutation, gene flow, or genetic drift are affecting allele frequencies.

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