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Properties of B cell epitopes

•The size is determined by the size, shape and amino acid residue of the Ag-binding site on the Ab molecule

•The binding involves weak non covalent interaction

•Native proteins generally hydrophilic amino acids

•Sequential or non-sequential amino acids

•Located in mobile regions

•Accessible

Properties of T cell epitopes

•T cell recognize Ag that has been processed in antigenic peptides with MHC

•Antigenic peptides recognized by T cells form trimolecular complexes with a T cell receptor and MHC molecules

•Internal peptides

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Q: Properties of Tcell and B cell epitopes?
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