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1250 minus 800 equals 450. This can be calculated by subtracting the hundreds, tens, and units places separately, starting from the right side. In this case, 0 minus 0 is 0, 5 minus 0 is 5, 2 minus 8 is -6, which requires borrowing 1 from the hundreds place to make it 12 minus 8, resulting in 4.
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