There are infinitely many rules that can generate the above sequence and it is always possible to find one which will give any number of your choice as the next.
One possible rule is
Un = (7n4 - 78n3 + 305n2 - 450n + 240)/12 for n = 1, 2, 3, ... and that gives the next number as 62.
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A single number, such as 2481020, cannot define a sequence.
Each following number in the sequence is being divided by 4. Therefore, the next number in the sequence is 3/4 = 0.75.
The next number is 0
The number that comes after 5099 is 5100. In the decimal number system, each number is followed by the next consecutive number in a sequence. Therefore, when counting up from 5099, the next number in the sequence is 5100.
10