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The number of combinations of 52 numbers taken 6 at a time is 52 * 51 * 50 * 49 * 48 * 47 / 6 / 5 / 4 / 3 / 2 = 20,358,520. The number of combinations of 36 numbers taken 5 at a time is 36 * 35 * 34 * 33 *32 / 5 / 4 / 3 / 2 = 376,992.

The odds are better with 5 out of 36 numbers, but the payout is probably less as well.

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