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13 x 17 = 221
The prime factors of 221 are 13 and 17. They're the only prime numbers that will divide evenly into 221 with no remainder.
231 / \ 3 77 / \ 7 11 / \ 11 1
Cateram r500= 221 and Ariel atom = 222
Besides the bus route number, the number 221 could also mean "Act 221" which is a sort of law. It could also mean a version number for a computer software.