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Since you have not bothered to specify any measurement units, I can only assume they are the same. And in that case, because 16x16 is greater than 5x12.5 one paver will be more than enough!
216
144 Get 160 to be safe.
72 Get 80 to be safe.
78.47 Pavers
49 that's over lapping on the edges, but it better than coming up short.