An infinite number.
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There are no pairs of 2-digit numbers with a difference of 90 if both numbers are positive or both negative. However, with one positive and one negative, there are 71 pairs.
Only 1 pair of prime numbers, 2 and 5, have a difference of 3. All prime numbers greater than 2 are odd so will have an even difference.
There are infinitely many pairs. An easy pair to remember is 0 and 19.
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There is only 1 pair of primes and they are 2*5.