It depends on the speed limits and how fast you drive. Traffic is also a big factor. And you have to stop for fuel and rest rooms.
AAA usually figures 50 miles an hour for interstate driving. Which would be about 300 miles.
If you have no traffic and are on the interstates, you could actually do about 400 miles in 6 hours and not break the speed limit of 70 miles an hour..
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The distance you can drive in 6 hours depends on your speed. If you are traveling at a constant speed of 60 miles per hour, you can drive 360 miles in 6 hours (60 miles/hour x 6 hours = 360 miles). However, if you are driving at a speed of 70 miles per hour, you can cover 420 miles in 6 hours (70 miles/hour x 6 hours = 420 miles). Therefore, the number of miles you can drive in 6 hours varies based on your speed.