Oh, dude, an F-statistic over 300 means there's a high likelihood that the differences between group means are not just due to random chance. It's like when you're playing darts and you hit the bullseye three times in a row - it's not just luck, you've got some serious skills going on. So yeah, in stats land, a high F-statistic is like hitting that statistical bullseye.
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the populations have an excess of heterozygotes
A high F statistic would results in a lower Sig, or P value, which would indicate that your results are significant.
The F statistic is statistic which may be used to test whether a regression accounts for a statistically significant proportion of the observed variation in the dependent variable.
The F-statistic is a test on ratio of the sum of squares regression and the sum of squares error (divided by their degrees of freedom). If this ratio is large, then the regression dominates and the model fits well. If it is small, the regression model is poorly fitting.
No The test statistic F-Test is a sum of squares, which by definition of squaring a number it must be positive.