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For a 3 digit number, the left most or the most significant digit cannot be zero. So it can be 1,2,3,4,5,6,7,8 or 9 which is 9 possibilities. The middle number can be 0,1,2,3,4,5,6,7,8,9 which is 10 possibilties but one of the digits has been chosen already as the first digit, so the possibilities are only 9. The right most number can be 0,1,2,3,4,5,6,7,8,9 which is 10 possibilities but two of the digits have been already used by the left most and the middle digits. That leaves only 8 possibilities. So the total number of three digit numbers that have three distinct digits is 9 x 9 x 8 = 81 x 8 = 648 possibilities
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There are 200 positive four digit integers that have 1 as their first digit and 2 or 5 as their last digit. There are 9000 positive four digit numbers, 1000 through 9999. 1000 of them have 1 as the first digit, 1000 through 1999. 200 of them have 2 or 5 as their last digit, 1002, 1005, 1012, 1015, ... 1992, and 1995.
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The largest 10-digit number with no digit repeated is 9876543210 !