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They were invented in India and brought to Europe by Arabs.
The original lock and key system was used by Egyptians over 4000 yrs. ago, as discovered by archaeologists. They were crude, and made of wood, but they were the forerunners of the lock and key system we still use today.
it was invented in eighteen twelve by Cheyenne architect James p Julian.
The first IV saline was used in 1832. Thomas Latta first used it during the cholera epidemic for patients who were sick.
I believe that they used the headright system to capture, buy, and sell African slaves, but i'm not a 100% sure.