The answer depends on the binomial.
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There is one way to determine weather each binomial is a factor of X-4. The division of polynomials is what determines each binomial.
(12x - 6)(12x + 6)
x2-64 = (x-8)(x+8) when factored
x2-12x+35 = (x-5)(x-7)
(m^5 - 10)(m^10 + 10m^5 + 100)