The answer will depend on the units used for 12 x 12. It should be blindingly obvious to anybody that the number of 12 inch x 12 inch tiles or 12 cm x 12 cm tiles will be quite different.
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Each tile covers 81 square inches. You have 1,296 square inches to cover. It will take 16 tiles to cover that area.
Approximately 73 square feet.
A tile measuring 2 foot by two foot (which, incidentally, is an unusually large tile) has an area of 4 square feet, so it would take 100 such tiles to cover a 400 square foot floor.
a 12 x 12 tile is 1 square foot. So, you would need 300 tiles to cover 300 square feet
It will take a minimum of 138 tiles. But it could take a lot more depending on the shape that you need to cover. For example, if it is a long narrow strip which is 1.1 ft wide then, unless you want to have a huge amount of mosaic, you will need 251 tiles.