The prime factorization of 16 is:
2 x 8
2 x 2 x 4
2 x 2 x 2 x 2.
There is not a pair of prime numbers that make 16.
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3 and 13 or 5 and 11
11 + 3 + 2
16 prime numbers
Every number has a factor pair of 1 and itself. Prime numbers have that as their only factor pair. Composite numbers have additional factor pairs. 7 = 1 x 7 9 = 1 x 9 16 = 1 x 16 and others 21 = 1 x 21 and others
The GCF is a single number so there cannot be any pair of numbers in the answer.