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The difference in x-coordinates is called the "run", and the difference in y-coordinates is the "rise".
In 2-dimensional space, it is the difference between their y-coordinates, in 3-dimensional space, it is the difference between their z-coordinates.
The difference in the X-coordinates (in the X-axis (horiztontal(left-right))) of two points is called the "run".
Calculate the slope as (difference of y-coordinates) / (difference of x-coordinates).
Calculate the difference of the y-coordinates, and divide it by the difference of the x-coordinates. That is the slope.