When it comes to differentiating, polar coordinates are more convenient because a derivative gives the slope of the tangent to a curve at some specific point. Since a curve is round, it makes more sense to use a circular approximation than a rectangular approximation, for sake of accuracy and precision. This doesn't make too much of a difference in terms of derivatives, but once you start hitting integrals, differentials, partials derivatives, and gradients of multivariable functions, you'll definitely want to be using radians instead of degrees.
Also, radians are generally preferred because they are all related by a factor of pi, a natural number, instead of 180 degrees, an arbitrary number, which makes them easier to calculate without a calculator (than degrees).
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To convert from degrees to radians, you can multiply by (pi / 180). Or use the Excel function to convert from degrees to radians. I am not sure about the name; you can find it under math functions.
Whenever you are not able to use degrees you use radians instead
Can you use trigonomic functions in real life situations? It's not like you carry a calculator with you everywhere... Very unlikely unless you have a job that requires trig skills.
Scroll down to related links and use the fine calculator "Convert radians to degrees and degrees to radians".
You need to give more information... you're probably going to use a trig identity though.