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We can not provide a numerical answer for this question as these (p and x) are variables and their value is not fixed (it varies). We have not been told the value of either variable. However we can simplify this expression.
-2p + 4x - 6p = 4x - 8p.
We have simply combined the -2p and the -6p, which we can do as 2 of something plus 6 of the same thing will always equal 8 of that thing.
-2 + -6 = -8. Therefore -2p + -6p equals -8p and hence the answer above.
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