After the death of Alexander the great, Aristotle fled to the the Greek island of Euboea to escape anti-Macedonian sentiment. There he lived the last year of his life on his mother's family estate near the city of Chalcis and died of natural causes in 322BC
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According to Sir David Ross's ARISTOTLE, "in 322 he died of a disease to which he had long been subject." (322 B.C.)