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It depends on how you define particle. For example, if ATOMS are considered particles, then the answer is no. Take Water, one of the most simple molecules. It contains one Oxygen atom (charge -2) and two Hydrogen atoms (charge+1 each). If you consider that atoms are really made of protons, neutrons, and electrons, ALL stable molecules, polar or not, have an equal number of protons (postive charged particles) and electrons (negative charged particles), else they would not be stable.

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Q: Do Polar molecules have an equal number of positive and negative particles?
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