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Well if you're talking about mitosis, the differences are insignificant.

If you're talking about meiosis, then the differences is that DNA replication only occurs prior to prophase 1 and does not occur prior to prophase 2 in order to produce haploid gamete cells, rather than diploid somatic cells.

I hope this was detailed enough. There are more differences, but I doubt you need to know them, based on your question.

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Q: How do prophase 1 and prophrase 2 differ?
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