I assume you want the numbers added together?
In which case, you simply total the numbers together.
8 + 20 + 18 + 21 = 67
If I've assumed wrongly, then more information is needed.
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18/20 + 8/20 - 5/20 = 21/20 or 1 and 1/20
4, 6, 8, 9, 10, 12, 14, 15, 16, 18, 20, 21
10 + 8 + 20 + 7 = 10 + 20 + 8 + 7 = 30 + 15 = 45
7/8 of 21 is 18 3/8
18/8 = 22/8 which simplifies to 21/4