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Two whole numbers cannot be simplified, but the fraction 48/64 can. To simply fractions, you have to find the GCF, or Greatest Common Factor.
One way to find the GCF is to find all the factors of each number and then find the largest one. For 48 and 64, that is:
48 - 1, 2, 3, 4, 6, 8, 12, 16, 24, 48
64 - 1, 2, 4, 8, 16, 32, 64
The GCF is 16, so divide both the numerator and denominator by 16.
The answer is 3/4.
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48 is 75% of 64
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