It depends on the situation.
Sometimes we have an equation like:
X - 14 = 7, in which we can solve for the letter (in this case, X, which equals 21).
Sometimes they are intended to be variables:
Y = X3-17X + 4, where the letters may be many numbers, but are restricted when other variables are known.
Other times, letters refer to specific constants:
e = approximately 2.718281828.
pi = approximately 3.141592654.
i = sqrt(-1) and is imaginary.
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In chemical symbols, superscripts following the letters tell us the number of charges on an ion.
The word "numbers" consists of 7 distinct letters. The number of permutations of these letters is calculated using the factorial of the number of letters, which is 7!. Therefore, the total number of permutations is 7! = 5,040.
I don't know if it's the only number but the number 4 has four letters in it's name.
4. (67 letters divided by 16 words = 4.4667 letters per word.)
One, two, three, four...doesn't take long to get to it...